⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18076253 | 0.85 | — | — | |
| SCHEMBL25184404 | 0.83 | — | — | |
| SCHEMBL1965746 | 0.83 | SSTR4 (0.41) | — | |
| SCHEMBL20336491 | 0.80 | ALDH1A1 (0.33) | — | |
| SCHEMBL5710573 | 0.80 | — | — | |
| SCHEMBL23355839 | 0.79 | DUT (0.31) | — | |
| SCHEMBL17544804 | 0.78 | — | — | |
| SCHEMBL14965578 | 0.78 | BLM (0.41) | — | |
| SCHEMBL23067161 | 0.77 | DUT (0.31) | — | |
| SCHEMBL19438890 | 0.77 | ALOX5 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159532-A1 | PARATHYROID HORMONE (PTH) RECEPTOR ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2023-05-25 | — | — | US | disclosed |
| WO-2023055827-A1 | PARATHYROID HORMONE (PTH) RECEPTOR ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2023-04-06 | — | — | WO | disclosed |
| EP-2968591-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151030-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |