Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.83 |
| ▸ | MAPT | P10636 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992707 | 0.98 | POLB (0.97) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL11925367 | 0.88 | ALDH1A1 (0.78) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5592639 | 0.87 | ALDH1A1 (0.76) | POLBALDH1A1MAPTKMT2AMEN1 | |
| Silver SCHEMBL7992706 | 0.87 | ALDH1A1 (0.76) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1610173 | 0.87 | POLB (0.76) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1612584 | 0.86 | L3MBTL1 (0.79) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1612844 | 0.85 | POLB (0.73) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8827915 | 0.85 | POLB (0.74) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL27804013 | 0.84 | ALDH1A1 (0.72) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8188675 | 0.84 | ALDH1A1 (0.72) | POLBALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2019-05-09 | — | — | US | disclosed |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2017-10-26 | — | — | US | disclosed |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2017-10-26 | — | — | US | disclosed |
| EP-3000468-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-03-30 | — | — | EP | disclosed |
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
| WO-2010075561-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-07-01 | — | — | WO | disclosed |
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |
| US-6746833-B2 | EXPOSING SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL INCLUDING SUPPORT AND AT LEAST THREE LIGHT-SENSITIVE LAYERS, DEVELOPING AT SPECIFIED TEMPERATURE, CONVERTING INFORMATION OF FORMED COLOR IMAGE TO DIGITAL IMAGE INFORMATION THROUGH IMAGE SENSOR | KONICA CORPORATION (JP) | 2004-06-08 | — | — | US | disclosed |
| US-6696230-B2 | EXPOSING SILVER HALIDE COLOR PHOTOGRAPHIC AND DEVELOPMENT; RECORDING INFORMATION CONVERTED THROUGH IMAGE SENSOR | KONICA CORPORATION (JP) | 2004-02-24 | — | — | US | disclosed |
| US-20040002022-A1 | Color image forming method and digital image forming method | KONICA CORPORATION (JP) | 2004-01-01 | — | — | US | disclosed |
| US-20030203324-A1 | Color image forming method and digital image forming method | KONICA CORPORATION (JP) | 2003-10-30 | — | — | US | disclosed |
| EP-0174177-B1 | HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | POLB 2233/4885ALDH1A1 4844/4885MAPT 2906/4885 |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | POLB 2287/4885ALDH1A1 4840/4885MAPT 2940/4885 |
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | POLB 2287/4885ALDH1A1 4840/4885MAPT 2940/4885 |
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | POLB 4782/4885ALDH1A1 3233/4885MAPT 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.