Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 6/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 6/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.40 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16772911 | 0.90 | TRPA1 (0.39) | TRPA1CHEK1PIK3CDABL1EGFR | |
| SCHEMBL16201161 | 0.83 | KDM1A (0.47) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125899 | 0.81 | PRMT1 (0.39) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125898 | 0.81 | PRMT1 (0.42) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125919 | 0.80 | PRMT1 (0.42) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125915 | 0.80 | MYC (0.42) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16201255 | 0.79 | CARM1 (0.46) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125906 | 0.79 | PRMT1 (0.49) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16125920 | 0.78 | PRMT6 (0.39) | CARM1PRMT1PRMT6PRMT8PRMT3 | |
| SCHEMBL16124903 | 0.78 | MAPK1 (0.37) | CARM1PRMT1PRMT6PRMT8PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970181-B1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2017-06-07 | — | — | EP | disclosed |
| US-20160108018-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-04-21 | — | — | US | disclosed |
| US-20160108018-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-04-21 | — | — | US | disclosed |
| EP-2970181-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9045455-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045455-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2015-06-02 | — | — | US | disclosed |
| WO-2014153208-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014153208-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140288128-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288128-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108018-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | CARM1 11/4885PRMT1 1/4885PRMT6 4/4885 |
| US-20140288128-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | CARM1 11/4885PRMT1 1/4885PRMT6 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.