Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30040032 | 0.84 | MAP3K5 (0.37) | KMT2AMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL30040835 | 0.84 | MAP3K5 (0.37) | KMT2AMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL5014075 | 0.80 | KMT2A (0.38) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL21777089 | 0.77 | AKR1C1 (0.47) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL10559629 | 0.77 | IKBKB (0.41) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL30931995 | 0.77 | AKR1C1 (0.47) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL422040 | 0.76 | IKBKB (0.47) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL29668334 | 0.76 | IKBKB (0.47) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL16101600 | 0.76 | MGAM (0.59) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL14843117 | 0.75 | IKBKB (0.46) | MAPTALDH1A1KDM4EHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968339-A1 | MK2 INHIBITORS AND USES THEREOF | Celgene Avilomics Research, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014149164-A1 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |