Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16102102 | 0.80 | KMT2A (0.48) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5014082 | 0.76 | NPC1 (0.38) | AKR1C1ROCK1ROCK2NEK2MAPT | |
| SCHEMBL21777089 | 0.74 | AKR1C1 (0.47) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30931995 | 0.74 | AKR1C1 (0.47) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30440659 | 0.73 | RET (0.42) | ROCK1ROCK2ALDH1A1LMNAMAPK1 | |
| SCHEMBL17241296 | 0.71 | ROCK1 (0.34) | CYP1A2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL5014078 | 0.68 | SMN1; SMN2 (0.57) | KMT2AMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL16180625 | 0.67 | CDK8 (0.49) | AKR1C1ROCK1ROCK2FLT3PLK4 | |
| SCHEMBL23593943 | 0.66 | AKR1C1 (0.70) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6689798 | 0.66 | AKR1C1 (0.70) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | KMT2A 3504/4885CYP1A2 2426/4885CYP3A4 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.