Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.45 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16101602 | 0.86 | RAB9A (0.56) | MGAMRAB9ACFTRPDGFRBPDGFRA | |
| SCHEMBL28280890 | 0.84 | MGAM (0.59) | MGAMRAB9ACFTRTOP2ATOP2B | |
| SCHEMBL8830542 | 0.80 | NQO2 (0.56) | MGAMRAB9ACFTRPDGFRBPDGFRA | |
| SCHEMBL8830540 | 0.80 | NQO2 (0.56) | MGAMRAB9ACFTRPDGFRBPDGFRA | |
| SCHEMBL16180625 | 0.79 | CDK8 (0.49) | PDGFRBPDGFRAKDRPDE10AAKR1C1 | |
| SCHEMBL28290522 | 0.78 | AKR1C3 (0.56) | KMT2AKDM4EMEN1MAPTALDH1A1 | |
| Urea SCHEMBL27348385 | 0.77 | MGAM (0.90) | MGAMRAB9ACFTRPDGFRBPDGFRA | |
| SCHEMBL29362497 | 0.77 | MGAM (0.71) | MGAMRAB9ACFTRTOP2ATOP2B | |
| SCHEMBL23372 | 0.77 | MGAM (0.71) | MGAMRAB9ACFTRTOP2ATOP2B | |
| SCHEMBL16102102 | 0.76 | KMT2A (0.48) | MGAMRAB9APDGFRBPDGFRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968339-A1 | MK2 INHIBITORS AND USES THEREOF | Celgene Avilomics Research, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014149164-A1 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |