Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16102946 | 0.83 | CYP4F2 (0.43) | CYP4F2CYP4A11LRRK2GSK3BDYRK1A | |
| SCHEMBL16100512 | 0.80 | CYP4F2 (0.40) | CYP4F2CYP4A11LRRK2GSK3BDYRK1A | |
| SCHEMBL16100520 | 0.77 | CYP4F2 (0.41) | CYP4F2CYP4A11LRRK2GSK3BDYRK1A | |
| SCHEMBL16120051 | 0.73 | CYP4F2 (0.38) | CYP4F2CYP4A11LRRK2GSK3BDYRK1A | |
| SCHEMBL5418828 | 0.69 | ROCK2 (0.58) | CYP4F2CYP4A11CHEK2HRH3NAMPT | |
| SCHEMBL17469481 | 0.69 | F10 (0.45) | CYP4F2CYP4A11LRRK2GSK3BCHEK2 | |
| SCHEMBL9119612 | 0.68 | MTNR1A (0.65) | — | |
| SCHEMBL9121362 | 0.68 | MTNR1A (0.61) | HRH3CYP3A4 | |
| SCHEMBL2094409 | 0.67 | HRH3 (0.49) | CYP4F2CYP4A11CHEK2HRH3NAMPT | |
| SCHEMBL5404376 | 0.66 | ROCK2 (0.54) | CYP4F2CYP4A11CHEK2HRH3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970220-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |