Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851360 | 0.84 | HTT (0.35) | HTTALDH1A1THRBMAPTCYP1A2 | |
| SCHEMBL4570831 | 0.74 | RECQL (0.40) | HTTALDH1A1THRBMAPTCYP1A2 | |
| SCHEMBL5254728 | 0.72 | ALDH1A1 (0.31) | HTTALDH1A1THRB | |
| SCHEMBL13650793 | 0.70 | MAPT (0.76) | HTTALDH1A1THRBMAPTCYP1A2 | |
| SCHEMBL19035330 | 0.68 | ADRA2A (0.39) | HTTALDH1A1MAPTCYP1A2 | |
| SCHEMBL25512499 | 0.67 | TRPA1 (0.35) | HTTALDH1A1THRBMAPTCYP1A2 | |
| SCHEMBL11035424 | 0.67 | IDO1 (0.36) | HTTALDH1A1THRBCYP3A4 | |
| SCHEMBL1155340 | 0.66 | MEN1 (0.48) | ALDH1A1THRBMAPTCYP3A4 | |
| SCHEMBL13552299 | 0.65 | TRPA1 (0.36) | HTTALDH1A1THRBMAPTCYP1A2 | |
| SCHEMBL16585968 | 0.65 | ALDH1A1 (0.47) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |
| EP-2433940-A1 | SPIROIMIDAZOLONE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-03-28 | — | — | EP | disclosed |