Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545927 | 0.85 | RIPK1 (0.46) | RIPK1HTR7IDH1 | |
| SCHEMBL1396904 | 0.81 | HTR7 (0.44) | HTR7 | |
| SCHEMBL1396815 | 0.76 | RIPK1 (0.40) | RIPK1ACHEFFAR1 | |
| SCHEMBL15608026 | 0.74 | DPP4 (0.47) | RIPK1DPP4ALDH1A1 | |
| SCHEMBL15667954 | 0.74 | DPP4 (0.47) | RIPK1DPP4ALDH1A1 | |
| SCHEMBL13738630 | 0.74 | DPP4 (0.47) | RIPK1DPP4ALDH1A1 | |
| SCHEMBL2260961 | 0.73 | CHRNB4 (0.50) | — | |
| SCHEMBL16105151 | 0.73 | USP2 (0.47) | RIPK1DPP4USP2ALDH1A1 | |
| SCHEMBL16105149 | 0.73 | USP2 (0.47) | RIPK1DPP4USP2ALDH1A1 | |
| SCHEMBL16105193 | 0.71 | ATM (0.49) | DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |