Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381944 | 0.82 | CA2 (0.53) | CA2GAAALDH1A1POLBMAPT | |
| SCHEMBL10959402 | 0.79 | CA2 (0.51) | CA2GAAL3MBTL1MAPTLMNA | |
| SCHEMBL3378813 | 0.78 | ALDH1A1 (0.48) | CA2ALDH1A1L3MBTL1CYP1A2POLB | |
| SCHEMBL19411809 | 0.76 | PIK3CD (0.45) | GAAALDH1A1NPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4167925 | 0.76 | PGR (0.54) | CA2GAAMAPT | |
| SCHEMBL19805150 | 0.75 | PDE3B (0.42) | GAATP53POLBMAPTLMNA | |
| SCHEMBL3308855 | 0.75 | ALDH1A1 (0.64) | CA2GAAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL28871521 | 0.73 | CA2 (0.51) | CA2GAAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL16109538 | 0.72 | BRD4 (0.69) | — | |
| SCHEMBL14094474 | 0.71 | SIRT2 (0.66) | GAAALDH1A1NPSR1L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978758-B1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-02-08 | — | — | EP | disclosed |
| EP-2978758-B1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-02-08 | — | — | EP | disclosed |
| EP-2978758-A1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2016-02-03 | — | — | EP | disclosed |
| US-9199988-B2 | Dihydroquinazolinone analogues | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-12-01 | — | — | US | disclosed |
| US-9199988-B2 | Dihydroquinazolinone analogues | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-12-01 | — | — | US | disclosed |
| US-20140296230-A1 | DIHYDROQUINAZOLINONE ANALOGUES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20140296230-A1 | DIHYDROQUINAZOLINONE ANALOGUES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| WO-2014154762-A1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014154762-A1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296230-A1 | DIHYDROQUINAZOLINONE ANALOGUES | MKI67, NQO2, CCNI | CA2 3150/4885GAA 673/4885ALDH1A1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.