Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 12/20 | 0.86 |
| ▸ | TGM2 | P21980 | 1/20 | 0.74 |
| ▸ | NT5E | P21589 | 1/20 | 0.67 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.66 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.63 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.63 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.63 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.62 |
| ▸ | HINT1 | P49773 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112811 | 1.00 | KRAS (0.86) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL16113018 | 0.92 | KRAS (1.00) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL16113628 | 0.92 | KRAS (1.00) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL16113020 | 0.92 | KRAS (1.00) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL17539263 | 0.92 | KRAS (0.88) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL17539261 | 0.91 | KRAS (1.00) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL851357 | 0.90 | TGM2 (0.85) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL21067722 | 0.90 | TGM2 (0.85) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL18769114 | 0.90 | TGM2 (0.85) | KRASTGM2NT5EFUT5P2RY2 | |
| SCHEMBL29429843 | 0.90 | TGM2 (0.85) | KRASTGM2NT5EFUT5P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970360-A1 | RAS INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160200-A9 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014160200-A1 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-10-02 | — | — | WO | disclosed |