SCHEMBL16113018

SCHEMBL16113018

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OCCNC(=O)CCl)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KRAS P01116 15/20 1.00
TGM2 P21980 1/20 0.72
NT5E P21589 1/20 0.65
FUT5 Q11128 1/20 0.65
P2RY2 P41231 1/20 0.62
P2RY4 P51582 1/20 0.62
P2RY6 Q15077 1/20 0.62
P2RX3 P56373 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16113628 1.00 KRAS (1.00) KRASTGM2NT5EFUT5P2RY2
SCHEMBL16113020 1.00 KRAS (1.00) KRASTGM2NT5EFUT5P2RY2
SCHEMBL17539280 0.97 KRAS (0.94) KRASTGM2NT5EFUT5
SCHEMBL22268204 0.94 KRAS (0.89) KRASTGM2NT5EFUT5P2RY2
SCHEMBL17539263 0.93 KRAS (0.88) KRASTGM2NT5EFUT5P2RY2
SCHEMBL17532543 0.93 KRAS (0.86) KRASTGM2NT5EFUT5
SCHEMBL16112811 0.92 KRAS (0.86) KRASTGM2NT5EFUT5P2RY2
SCHEMBL16112808 0.92 KRAS (0.86) KRASTGM2NT5EFUT5P2RY2
SCHEMBL17539277 0.92 KRAS (0.85) KRASTGM2NT5EFUT5
SCHEMBL17539261 0.90 KRAS (1.00) KRASTGM2NT5EFUT5P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353912-A1 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES UNIV NEW YORK (US) 2025-11-20 US claimed
WO-2025226775-A2 COMPOSITIONS AND METHODS FOR BINDING TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY (US) 2025-10-30 WO claimed
EP-4543931-A2 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES New York University (US) 2025-04-30 EP claimed
CN-119866347-A Compositions and methods comprising antibodies conjugated to covalent peptide conjugates 纽约大学 2025-04-22 CN claimed
US-20240327542-A1 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY 2024-10-03 US claimed
WO-2024091511-A1 HETEROCYCLIC TEAD INHIBITORS LIGHT HORSE THERAPEUTICS, INC. (US) 2024-05-02 WO claimed
WO-2023250391-A9 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY (US) 2024-04-25 WO claimed
WO-2023250391-A2 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY (US) 2023-12-28 WO claimed
CN-122080069-A Phospholipid compounds and uses thereof 2026-05-26 CN disclosed
CN-122055153-A EGFR inhibitors for treating EGFR exon 20 mutation positive lung cancer 安塔列斯疗法股份有限公司 2026-05-15 CN disclosed
US-20260130893-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2026-05-14 US disclosed
CN-122029161-A Crystalline forms of PI3K inhibitors and uses thereof 蝎子疗法股份有限公司 2026-05-12 CN disclosed
US-20260125366-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-4735453-A1 KRAS MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2026-05-06 EP disclosed
US-10723753-B2 Ras inhibitors and uses thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-07-28 US disclosed
US-20160046661-A1 RAS INHIBITORS AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2016-02-18 US disclosed
US-20160046661-A1 RAS INHIBITORS AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2016-02-18 US disclosed
EP-2970360-A1 RAS INHIBITORS AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2016-01-20 EP disclosed
WO-2014160200-A9 RAS INHIBITORS AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2014-11-27 WO disclosed
WO-2014160200-A1 RAS INHIBITORS AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2014-10-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160046661-A1 RAS INHIBITORS AND USES THEREOF KRAS, NRAS, RASGRP1 KRAS 1/4885TGM2 3081/4885NT5E 2879/4885
US-20250353912-A1 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES MICA, CD74, HLA-DRB1 KRAS 2277/4885TGM2 1657/4885NT5E 3012/4885
US-20260130893-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 KRAS 186/4885TGM2 2813/4885NT5E 1962/4885
US-10723753-B2 Ras inhibitors and uses thereof KRAS, NRAS, RASGRP1 KRAS 1/4885TGM2 3081/4885NT5E 2879/4885
US-20260125366-A1 METHODS FOR TREATING CANCER AKT2, AKT3, PIK3R5 KRAS 132/4885TGM2 4436/4885NT5E 1276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.