SCHEMBL851357

SCHEMBL851357

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)[nH]c(N)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.85

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.85
NT5E P21589 1/20 0.80
KRAS P01116 5/20 0.79
FUT5 Q11128 1/20 0.78
P2RX3 P56373 2/20 0.75
P2RY2 P41231 3/20 0.71
P2RY4 P51582 1/20 0.71
P2RY6 Q15077 1/20 0.71
DCPS Q96C86 1/20 0.68
P2RY1 P47900 3/20 0.67
SRC P12931 1/20 0.67
P2RX1 P51575 1/20 0.67
P2RX4 Q99571 1/20 0.67
P2RX2 Q9UBL9 1/20 0.67
ALDH1A1 P00352 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
HINT1 P49773 1/20 0.66
IMPDH2 P12268 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29429843 1.00 TGM2 (0.85) TGM2NT5EKRASFUT5P2RX3
SCHEMBL18769114 1.00 TGM2 (0.85) TGM2NT5EKRASFUT5P2RX3
SCHEMBL21067722 1.00 TGM2 (0.85) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL3333959 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL5809658 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL17367368 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL1304258 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL19691775 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL18784960 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL2593095 0.97 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4389214-A2 USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN Thorel, Jean-Noël (FR) 2024-06-26 EP claimed
EP-3466419-B1 USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN THOREL JEAN NOEL (FR) 2024-05-08 EP claimed
CN-117050928-B Sf9 cell strain free of rhabdovirus pollution and efficient screening method thereof 简达生物医药(南京)有限公司 2024-03-05 CN claimed
US-20230331809-A1 FUSION PROTEINS COMPRISING A LIGAND-RECEPTOR PAIR AND A BIOLOGICALLY FUNCTIONAL PROTEIN ZYMEWORKS BC INC. (CA) 2023-10-19 US claimed
CN-116171167-A Fusion proteins comprising ligand-receptor pairs and biofunctional proteins 酵活生物制药有限公司 2023-05-26 CN claimed
EP-4182357-A1 FUSION PROTEINS COMPRISING A LIGAND-RECEPTOR PAIR AND A BIOLOGICALLY FUNCTIONAL PROTEIN Zymeworks BC Inc. (CA) 2023-05-24 EP claimed
WO-2022016270-A9 FUSION PROTEINS COMPRISING A LIGAND-RECEPTOR PAIR AND A BIOLOGICALLY FUNCTIONAL PROTEIN ZYMEWORKS BC INC. (CA) 2023-02-02 WO claimed
CN-216629999-U Filtering device for marine plankton GP4G 广州奥利生物科技有限公司 2022-05-31 CN claimed
WO-2022016270-A1 FUSION PROTEINS COMPRISING A LIGAND-RECEPTOR PAIR AND A BIOLOGICALLY FUNCTIONAL PROTEIN ZYMEWORKS INC. (CA) 2022-01-27 WO claimed
US-20260146262-A1 METHODS OF LIPID NANOPARTICLE PRODUCTION IN CROSS-MIXERS MODERNATX, INC. (US) 2026-05-28 US disclosed
US-20260137803-A1 LIPID NANOPARTICLES AND METHODS OF MANUFACTURE AND USE THEREOF GENZYME CORP (US) 2026-05-21 US disclosed
EP-4727914-A1 COMPOUNDS AND COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS ModernaTX, Inc. (US) 2026-04-22 EP disclosed
US-12594233-B2 Fat and/or wax activated by means of the water-insoluble fraction of Carica papaya sap ISP INVESTMENTS LLC (US) 2026-04-07 US disclosed
US-12595226-B2 Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents MODERNATX, INC. (US) 2026-04-07 US disclosed
US-20110246081-A1 Metabolomics-Based Identification of Disease-Causing Agents GEORGIA TECH RESEARCH CORPORATION (US) 2011-10-06 US disclosed
US-7869957-B2 Methods and systems to identify operational reaction pathways THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-11 US disclosed
US-20100280803-A1 Compositions and Methods for Modeling Saccharomyces cerevisiae Metabolism THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2010-11-04 US disclosed
EP-2230312-A1 Probe compound for detecting and isolating enzymes and means and methods using the same Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2010-09-22 EP disclosed
US-7751981-B2 Articles of manufacture and methods for modeling Saccharomyces cerevisiae metabolism THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-07-06 US disclosed
US-20090186358-A1 Pathway Analysis of Cell Culture Phenotypes and Uses Thereof WYETH (US) 2009-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12594233-B2 Fat and/or wax activated by means of the water-insoluble fraction of Carica papaya sap LIPC, LIPA, PNLIP TGM2 2897/4885NT5E 2636/4885KRAS 3785/4885
US-12595226-B2 Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents LNPK, PCTP, PLTP TGM2 3144/4885NT5E 4389/4885KRAS 2659/4885
US-20260146262-A1 METHODS OF LIPID NANOPARTICLE PRODUCTION IN CROSS-MIXERS ELAVL1, IGF2BP2, FUS TGM2 4209/4885NT5E 3732/4885KRAS 1906/4885
US-20260137803-A1 LIPID NANOPARTICLES AND METHODS OF MANUFACTURE AND USE THEREOF CD2BP2, CD2, CD4 TGM2 984/4885NT5E 1451/4885KRAS 2105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.