Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1611441 | 0.88 | HDAC1 (0.40) | HSD11B1HDAC1HDAC6RAB9AALDH1A1 | |
| SCHEMBL1612419 | 0.85 | HSD11B1 (0.43) | HSD11B1HDAC1HDAC6RAB9AALDH1A1 | |
| SCHEMBL1611042 | 0.84 | ALDH1A1 (0.39) | HSD11B1HDAC1HDAC6ALDH1A1TP53 | |
| SCHEMBL1493574 | 0.76 | TP53 (0.41) | HSD11B1ALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL1612000 | 0.76 | HTT (0.45) | ALDH1A1SMN1; SMN2TP53LMNAHTT | |
| SCHEMBL1612083 | 0.75 | THRB (0.42) | ALDH1A1SMN1; SMN2TP53LMNAHTT | |
| SCHEMBL1493310 | 0.75 | ALDH1A1 (0.42) | HSD11B1ALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL1493414 | 0.74 | HSD11B1 (0.45) | HSD11B1ALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL1493469 | 0.73 | MAPT (0.44) | ALDH1A1SMN1; SMN2TP53HTTTSHR | |
| SCHEMBL1493380 | 0.72 | MAPT (0.45) | HSD11B1ALDH1A1TP53LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | HSD11B1 1201/4885HDAC1 442/4885HDAC6 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.