Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 9/20 | 0.39 |
| ▸ | CTSS | P25774 | 9/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16119290 | 0.87 | ACE (0.48) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL16228847 | 0.87 | ACE (0.48) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL6908318 | 0.86 | KLK5 (0.44) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL16228157 | 0.86 | KLK5 (0.44) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL16119293 | 0.86 | KLK5 (0.44) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL16119295 | 0.83 | CTSS (0.41) | CTSKCTSSCTSLCTSBSCN9A | |
| SCHEMBL17483752 | 0.83 | CTSK (0.38) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL8909470 | 0.82 | ALDH1A1 (0.46) | CTSKCTSSCACNA1BALDH1A1KDM4E | |
| SCHEMBL26043016 | 0.82 | CA1 (0.40) | ACECTSKCTSSCTSLCTSB | |
| SCHEMBL17483753 | 0.81 | JAK3 (0.47) | ACECTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970224-B1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| WO-2014152127-A1 | DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014152134-A1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |