SCHEMBL16122452

SCHEMBL16122452

Cc1cc(C#N)c(F)c2c1sc1ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.40
MAPT P10636 5/20 0.40
L3MBTL1 Q9Y468 3/20 0.40
POLB P06746 2/20 0.40
HCRTR1 O43613 2/20 0.40
LMNA P02545 1/20 0.40
TP53 P04637 2/20 0.36
TSHR P16473 1/20 0.36
PTPN1 P18031 1/20 0.34
KDM4E B2RXH2 3/20 0.33
RAB9A P51151 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HPGD P15428 2/20 0.33
RXFP1 Q9HBX9 2/20 0.33
TNKS O95271 1/20 0.33
TNKS2 Q9H2K2 1/20 0.33
GAA P10253 1/20 0.33
ATM Q13315 1/20 0.33
PRNP P04156 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17540374 0.87 TNKS (0.36) ALDH1A1MAPTHCRTR1TP53PTPN1
SCHEMBL16122442 0.81 TNKS (0.36) ALDH1A1MAPTHCRTR1TP53PTPN1
SCHEMBL25812789 0.74 ALDH1A1 (0.50) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL17546148 0.74 GPR3 (0.38) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL17891973 0.72 GPR3 (0.46) ALDH1A1MAPTHCRTR1PTPN1KDM4E
SCHEMBL14133854 0.72 MAPT (0.51) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL29178545 0.72 ALDH1A1 (0.47) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL14798075 0.70 GPR3 (0.48) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL31208546 0.70 GPR3 (0.48) ALDH1A1MAPTL3MBTL1POLBHCRTR1
SCHEMBL16273146 0.70 TSHR (0.48) ALDH1A1MAPTL3MBTL1POLBHCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014146750-A1 SYNTHETIC BUILDING BLOCKS FOR THE PRODUCTION OF MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2014-09-25 WO disclosed