Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.49 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.49 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 0.49 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.49 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.49 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL161400 | 0.93 | HTR7 (0.50) | NOTUMKDM4EMEN1KMT2APOLB | |
| Alpha-Ketoglutaric Acid SCHEMBL162747 | 0.92 | NOTUM (0.48) | NOTUMKDM4EMEN1KMT2APOLB | |
| Malonic Acid SCHEMBL160931 | 0.90 | HDAC1 (0.50) | NOTUMKDM4EMEN1KMT2APOLB | |
| Glycolic Acid SCHEMBL162066 | 0.90 | HDAC1 (0.47) | NOTUMKDM4EMEN1KMT2APOLB | |
| Glutamic Acid SCHEMBL158773 | 0.85 | GRM8 (0.49) | NOTUMKDM4EMEN1KMT2APOLB | |
| SCHEMBL162670 | 0.85 | MAOA (0.46) | KDM4EMEN1KMT2AHTR7DRD2 | |
| Fumaric Acid SCHEMBL159723 | 0.85 | MEN1 (0.46) | KDM4EMEN1KMT2APOLBMAPT | |
| Maleic Acid SCHEMBL161823 | 0.85 | MEN1 (0.46) | KDM4EMEN1KMT2APOLBMAPT | |
| Bromide SCHEMBL161201 | 0.83 | MAOA (0.45) | KDM4EHTR7DRD2DRD3HDAC1 | |
| Iodide SCHEMBL162027 | 0.83 | MAOA (0.45) | KDM4EMEN1KMT2AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |