Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.43 |
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL159723 | 1.00 | MEN1 (0.46) | MEN1KMT2AMAPTTAAR1HDAC1 | |
| Malonic Acid SCHEMBL160931 | 0.85 | HDAC1 (0.50) | MEN1KMT2AMAPTHDAC1HDAC6 | |
| Glycolic Acid SCHEMBL162066 | 0.85 | HDAC1 (0.47) | MEN1KMT2AMAPTHDAC1HDAC6 | |
| Succinic Acid SCHEMBL161277 | 0.85 | NOTUM (0.54) | MEN1KMT2AMAPTHDAC1HDAC6 | |
| SCHEMBL162670 | 0.84 | MAOA (0.46) | MEN1KMT2AHDAC1HDAC6DRD2 | |
| Adipic Acid SCHEMBL161400 | 0.82 | HTR7 (0.50) | MEN1KMT2AMAPTHDAC1HDAC6 | |
| Iodide SCHEMBL162027 | 0.82 | MAOA (0.45) | MEN1KMT2AHDAC1HDAC6DRD2 | |
| Bromide SCHEMBL161201 | 0.82 | MAOA (0.45) | HDAC1HDAC6DRD2DRD3HTR7 | |
| Sulfuric Acid SCHEMBL158676 | 0.81 | HSD17B10 (0.49) | MEN1KMT2AHDAC1HDAC6DRD2 | |
| Phosphoric Acid SCHEMBL166017 | 0.81 | HDAC1 (0.49) | MEN1KMT2AHDAC1HDAC6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |