Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.47 |
| ▸ | AKT2 | P31751 | 3/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17512055 | 1.00 | AKT1 (0.47) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL17512062 | 0.87 | OPRL1 (0.51) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16127805 | 0.87 | OPRL1 (0.51) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16101186 | 0.84 | OPRM1 (0.47) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16101183 | 0.84 | OPRM1 (0.47) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL17512053 | 0.84 | OPRM1 (0.55) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16127791 | 0.84 | OPRM1 (0.55) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16102881 | 0.82 | OPRM1 (0.52) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16102880 | 0.82 | OPRM1 (0.52) | AKT1AKT2AKT3OPRM1OPRD1 | |
| SCHEMBL16100838 | 0.81 | OPRM1 (0.49) | AKT1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-02-25 | — | — | US | disclosed |
| WO-2014153529-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | OPRL1, OPRK1, OPRM1 | AKT1 3067/4885AKT2 3294/4885AKT3 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.