Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16127805 | 1.00 | OPRL1 (0.51) | OPRL1OPRM1OPRD1OPRK1ACHE | |
| SCHEMBL17512053 | 0.89 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL16127791 | 0.89 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL16100837 | 0.88 | OPRM1 (0.49) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL16100838 | 0.88 | OPRM1 (0.49) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL16127804 | 0.87 | AKT1 (0.47) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL17512055 | 0.87 | AKT1 (0.47) | OPRL1OPRM1OPRD1OPRK1CHRM1 | |
| SCHEMBL16102881 | 0.87 | OPRM1 (0.52) | OPRL1OPRM1OPRD1OPRK1ACHE | |
| SCHEMBL16102880 | 0.87 | OPRM1 (0.52) | OPRL1OPRM1OPRD1OPRK1ACHE | |
| SCHEMBL17512034 | 0.86 | OPRM1 (0.54) | OPRL1OPRM1OPRD1OPRK1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | OPRL1, OPRK1, OPRM1 | OPRL1 1/4885OPRM1 3/4885OPRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.