Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 3/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24533998 | 0.80 | ULK1 (0.39) | PARP1CDK1MAPTBRAF | |
| SCHEMBL11565241 | 0.80 | PARP1 (0.45) | PARP1S1PR1MAPTCDC7DBF4 | |
| SCHEMBL22361949 | 0.80 | PARP1 (0.45) | PARP1S1PR1MAPTCDC7DBF4 | |
| SCHEMBL31436452 | 0.80 | CDK1 (0.36) | PARP1S1PR1CDK1MAPTCDC7 | |
| SCHEMBL2298425 | 0.80 | PARP1 (0.45) | PARP1S1PR1MAPTCDC7DBF4 | |
| SCHEMBL2431453 | 0.76 | PARP1 (0.42) | PARP1S1PR1MAPTQPCTCDC7 | |
| SCHEMBL13759404 | 0.76 | PARP1 (0.42) | PARP1S1PR1CACNA1HMAPTQPCT | |
| SCHEMBL13759405 | 0.76 | PARP1 (0.45) | PARP1S1PR1CDK1MAPTQPCT | |
| SCHEMBL30792066 | 0.76 | KIF11 (0.34) | PARP1CDK1CDC7DBF4 | |
| SCHEMBL15093877 | 0.75 | PARP1 (0.44) | PARP1S1PR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153001-A1 | COMBINATION THERAPY FOR TREATING CANCER | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |