Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 3/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29285163 | 0.78 | PARP1 (0.41) | PARP1MAPTPOLBQPCTALDH1A1 | |
| SCHEMBL16129491 | 0.76 | PARP1 (0.46) | PARP1MAPTS1PR1QPCTCDK1 | |
| SCHEMBL2298425 | 0.75 | PARP1 (0.45) | PARP1MAPTS1PR1P2RY14TEK | |
| SCHEMBL22361949 | 0.75 | PARP1 (0.45) | PARP1MAPTS1PR1POLBALDH1A1 | |
| SCHEMBL11565241 | 0.75 | PARP1 (0.45) | PARP1MAPTS1PR1ALDH1A1BRAF | |
| SCHEMBL2424011 | 0.74 | CTSS (0.39) | PARP1MAPTS1PR1P2RY14ALOX5AP | |
| SCHEMBL2426912 | 0.74 | ALDH1A1 (0.31) | POLBALDH1A1L3MBTL1 | |
| SCHEMBL15093877 | 0.73 | PARP1 (0.44) | PARP1MAPTS1PR1P2RY14TEK | |
| Hydrochloric Acid SCHEMBL20562251 | 0.72 | PARP1 (0.43) | PARP1MAPTS1PR1P2RY14TEK | |
| SCHEMBL11869664 | 0.72 | ALDH1A1 (0.50) | PARP1MAPTPOLBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557120-B2 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557120-B2 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070004714-A1 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-20070004714-A1 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004714-A1 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity | CCR2, CCR1, CCR8 | PARP1 3206/4885MAPT 4550/4885S1PR1 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.