Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26815267 | 0.78 | HTR2C (0.41) | — | |
| SCHEMBL24665500 | 0.74 | HSD17B13 (0.44) | ALDH1A1 | |
| SCHEMBL9802974 | 0.74 | HSD17B13 (0.41) | GSK3AGSK3BKDM4EALDH1A1MAPK1 | |
| SCHEMBL4490436 | 0.74 | POLB (0.32) | ALDH1A1POLB | |
| SCHEMBL21846831 | 0.74 | CRBN (0.34) | KDM4EALDH1A1POLB | |
| SCHEMBL10376057 | 0.72 | PIK3CD (0.34) | PKMKDM4EALDH1A1MAPK1PIK3CD | |
| SCHEMBL23028988 | 0.72 | POLB (0.32) | POLB | |
| SCHEMBL29776954 | 0.72 | CDK4 (0.33) | PKM | |
| SCHEMBL26039730 | 0.71 | TSHR (0.42) | ACACB | |
| SCHEMBL23260078 | 0.71 | POLB (0.36) | P2RX3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846638-B2 | Macrocyclic nucleoside phosphoramidate derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2014-09-30 | — | — | US | disclosed |