Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | FABP6 | P51161 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279929 | 0.83 | ALDH1A1 (0.48) | ALDH1A1POLBKDM4EALOX15MEN1 | |
| SCHEMBL13466398 | 0.83 | ALDH1A1 (0.64) | ALDH1A1POLBAKR1C3FABP6KDM4E | |
| SCHEMBL18376152 | 0.81 | HPGD (0.64) | ALDH1A1HCAR2KDM4EKMT2AATM | |
| SCHEMBL12513597 | 0.79 | MEN1 (0.64) | ALDH1A1POLBFABP6KDM4EMEN1 | |
| SCHEMBL12286133 | 0.79 | HPGD (0.64) | ALDH1A1POLBAKR1C3KDM4EMEN1 | |
| SCHEMBL10211716 | 0.78 | ALDH1A1 (0.69) | ALDH1A1POLBAKR1C3KDM4EMEN1 | |
| SCHEMBL15107941 | 0.78 | ALDH1A1 (0.58) | ALDH1A1POLBAKR1C3KDM4ENAMPT | |
| SCHEMBL12104580 | 0.77 | SMN1; SMN2 (0.54) | ALDH1A1HCAR2KDM4EMEN1KMT2A | |
| SCHEMBL5821065 | 0.75 | CYP46A1 (0.49) | ALDH1A1HCAR2MEN1KMT2AATM | |
| SCHEMBL16132010 | 0.74 | ALDH1A1 (0.49) | ALDH1A1POLBKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | CSNK1G1, PRKCE, PHKG1 | ALDH1A1 4487/4885POLB 1057/4885AKR1C3 3379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.