Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12343371 | 0.73 | MEN1 (0.47) | THRBMEN1KMT2A | |
| SCHEMBL20073627 | 0.73 | NNMT (0.40) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL26874288 | 0.73 | GSK3B (0.37) | NNMT | |
| SCHEMBL29947373 | 0.73 | NNMT (0.40) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL24805156 | 0.72 | L3MBTL1 (0.40) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL16333365 | 0.69 | NNMT (0.42) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL28662886 | 0.69 | NNMT (0.42) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL29577063 | 0.69 | NNMT (0.42) | MAPTNNMTMEN1KMT2A | |
| SCHEMBL30696900 | 0.69 | NNMT (0.37) | NNMT | |
| SCHEMBL625580 | 0.68 | SMN1; SMN2 (0.47) | NNMTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784078-A1 | Benzoxepin pi3k inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2014-10-01 | — | — | EP | disclosed |