Sugi Predict

Sugi Predict / Compounds / SCHEMBL16137348

SCHEMBL16137348

SCHEMBL16137348

Cc1ccccc1S(=O)(=O)Nc1cc(-c2c(O)ccc3ccccc23)c(O)c2ccccc12

nearest known ligand 0.66

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.66
▸ HSP90AA1 P07900 13/20 0.56
▸ HSP90AB1 P08238 13/20 0.56
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ HSD11B1 P28845 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ G6PD P11413 1/20 0.49
▸ MAP1LC3B Q9GZQ8 1/20 0.49
▸ HSD17B1 P14061 1/20 0.48
▸ HSD17B2 P37059 1/20 0.48
▸ PGAM1 P18669 1/20 0.48
▸ HCRTR1 O43613 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13509808 0.93 STAT3 (0.63) STAT3HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL13509797 0.90 MEN1 (0.64) STAT3HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL13509791 0.90 MEN1 (0.64) STAT3HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL13509846 0.89 STAT3 (0.61) STAT3HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL13509924 0.87 STAT3 (0.63) STAT3HSP90AA1HSP90AB1PGAM1HCRTR1
SCHEMBL13509839 0.87 STAT3 (0.63) STAT3HSP90AA1HSP90AB1HSD17B1HSD17B2
SCHEMBL13509942 0.87 STAT3 (0.63) STAT3HSP90AA1HSP90AB1HSD11B1PGAM1
SCHEMBL13509869 0.86 STAT3 (0.61) STAT3HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL13509852 0.86 STAT3 (0.61) STAT3HSP90AA1HSP90AB1HSD11B1PGAM1
SCHEMBL13509855 0.86 STAT3 (0.71) STAT3HSP90AA1HSP90AB1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150051233-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS BAYLOR COLLEGE OF MEDICINE 2015-02-19 — — US disclosed
US-20150031714-A1 METHODS AND COMPOSITIONS FOR PREVENTION OF ALLERGIC REACTION BAYLOR COLLEGE OF MEDICINE 2015-01-29 — — US disclosed
US-20150024032-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA BAYLOR COLLEGE OF MEDICINE 2015-01-22 — — US disclosed
US-20140296270-A1 STAT3 Inhibitors BAYLOR COLLEGE OF MEDICINE (US) 2014-10-02 — — US disclosed
US-20110312984-A1 STAT3 INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051233-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS STAT3, MMP1, MMP8 STAT3 1/4885HSP90AA1 347/4885HSP90AB1 230/4885
US-20150024032-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA PYGM, MYLK2, STAT3 STAT3 3/4885HSP90AA1 508/4885HSP90AB1 346/4885
US-20140296270-A1 STAT3 Inhibitors STAT3, STAT1, JAK2 STAT3 1/4885HSP90AA1 231/4885HSP90AB1 254/4885
US-20150031714-A1 METHODS AND COMPOSITIONS FOR PREVENTION OF ALLERGIC REACTION JAK2, STAT3, STAT6 STAT3 2/4885HSP90AA1 1192/4885HSP90AB1 937/4885
US-20110312984-A1 STAT3 INHIBITORS STAT3, STAT1, JAK2 STAT3 1/4885HSP90AA1 231/4885HSP90AB1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.