Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30488023 | 0.84 | DHFR (0.56) | DHFRHTTP2RX3P2RX2 | |
| SCHEMBL1388631 | 0.84 | DHFR (0.56) | DHFRHTTP2RX3P2RX2 | |
| SCHEMBL1614076 | 0.82 | DHFR (0.55) | DHFRHTTADORA1P2RX3P2RX2 | |
| SCHEMBL1612609 | 0.80 | DHFR (0.51) | DHFR | |
| SCHEMBL27641705 | 0.80 | DHFR (0.57) | DHFRHTTADORA1P2RX3P2RX2 | |
| SCHEMBL27612564 | 0.79 | ADORA1 (0.61) | DHFRADORA1P2RX3P2RX2ADORA2A | |
| SCHEMBL4335673 | 0.78 | DHFR (0.56) | DHFRADORA1P2RX3P2RX2ADORA2A | |
| Hydrochloric Acid SCHEMBL27641701 | 0.78 | DHFR (0.56) | DHFRHTTADORA1P2RX3P2RX2 | |
| SCHEMBL1612797 | 0.77 | DHFR (0.45) | DHFRADORA1 | |
| SCHEMBL5943356 | 0.76 | DHFR (0.64) | DHFRHTTP2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | DHFR 2398/4885HTT 4095/4885ADORA1 3982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.