Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188897 | 0.83 | DHFR (0.54) | DHFRFGFR1LCKKDRJAK3 | |
| SCHEMBL1612797 | 0.81 | DHFR (0.45) | DHFRFGFR1 | |
| SCHEMBL1613741 | 0.80 | DHFR (0.55) | DHFR | |
| SCHEMBL27612441 | 0.77 | DHFR (0.55) | DHFRFGFR1LCKKDRJAK3 | |
| SCHEMBL4464780 | 0.76 | FGFR1 (0.55) | DHFRFGFR1LCKKDRJAK3 | |
| SCHEMBL18676904 | 0.74 | LMNA (0.42) | — | |
| SCHEMBL1936800 | 0.74 | DHFR (0.57) | DHFRFGFR1 | |
| SCHEMBL4357670 | 0.73 | DHFR (0.50) | DHFRFGFR1LCKKDRJAK3 | |
| SCHEMBL27631706 | 0.72 | DHFR (0.68) | DHFRFGFR1LCKKDRJAK3 | |
| SCHEMBL1613564 | 0.71 | DHFR (0.38) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | DHFR 2398/4885FGFR1 816/4885LCK 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.