SCHEMBL1614075

SCHEMBL1614075

C#CC(C)(c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 18/20 0.63
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
ALOX12 P18054 1/20 0.33
NFKB1 P19838 1/20 0.33
MAPK1 P28482 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16927790 1.00 ALOX5 (0.63) ALOX5MEN1ALDH1A1TP53CYP1A2
SCHEMBL7638013 0.84 ALOX5 (0.54) ALOX5
SCHEMBL1894728 0.75 ALOX5 (0.44) ALOX5
SCHEMBL6436758 0.75 ALOX5 (0.44) ALOX5
SCHEMBL9208627 0.72 ALOX5 (0.62) ALOX5MEN1ALDH1A1TP53CYP1A2
SCHEMBL9208616 0.72 ALOX5 (0.62) ALOX5MEN1ALDH1A1TP53CYP1A2
SCHEMBL8357228 0.69 ALOX5 (0.64) ALOX5MEN1ALDH1A1TP53CYP1A2
SCHEMBL2880522 0.69 ALOX5 (0.64) ALOX5MEN1ALDH1A1TP53CYP1A2
SCHEMBL13696966 0.67 ALOX5 (0.61) ALOX5
SCHEMBL1807930 0.66 ALOX5 (1.00) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210121440-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2021-04-29 US claimed
US-20190298689-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2019-10-03 US claimed
US-20170296509-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2017-10-19 US claimed
US-20150272926-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2015-10-01 US claimed
US-20140066494-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2014-03-06 US claimed
US-20130085174-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C (DE) 2013-04-04 US claimed
US-20110086907-A1 ACNE TREATMENT ZOUBOULIS CHRISTOS C 2011-04-14 US claimed
CN-101277614-A Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway ACCELALOX INC (US) 2008-10-01 CN claimed
EP-1947942-A2 METHODS FOR BONE TREATMENT BY MODULATING AN ARACHIDONIC ACID METABOLIC OR SIGNALING PATHWAY Accelalox, Inc. (US) 2008-07-30 EP claimed
WO-2007022427-A9 METHODS FOR BONE TREATMENT BY MODULATING AN ARACHIDONIC ACID METABOLIC OR SIGNALING PATHWAY ACCELALOX INC (US) 2007-10-18 WO claimed
WO-2007022427-A2 METHODS FOR BONE TREATMENT BY MODULATING AN ARACHIDONIC ACID METABOLIC OR SIGNALING PATHWAY ACCELALOX, INC. (US) 2007-02-22 WO claimed
US-7132441-B2 Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor G.D. SEARLE & CO. (US) 2006-11-07 US claimed
EP-1385505-B1 ACNE TREATMENT WITH LIPOOXIGENASE INHIBITORS ZOUBOULIS CHRISTOS (DE) 2006-07-05 EP claimed
EP-0833622-B1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR SEARLE & CO (US) 2005-08-10 EP claimed
US-20040259920-A1 Lipoxygenase inhibitors as antiinflammatory agents for treatment of acne by mouth or topical application ZOUBOULIS CHRISTOS C (DE) 2004-12-23 US claimed
US-20020143033-A1 Immunosuppresive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor G.D. SEARLE & CO. 2002-10-03 US claimed
EP-0888127-B1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS SEARLE & CO (US) 2001-12-12 EP claimed
US-6136839-A USING A SULFONE OR SULFOAMIDE BENZENE COMPOUND G. D. SEARLE & CO. (US) 2000-10-24 US claimed
CN-101277614-A Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway ACCELALOX INC (US) 2008-10-01 CN disclosed
US-6136839-A USING A SULFONE OR SULFOAMIDE BENZENE COMPOUND G. D. SEARLE & CO. (US) 2000-10-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020143033-A1 Immunosuppresive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor ALOX5, ALOX15B, ALOX15 ALOX5 1/4885MEN1 4610/4885ALDH1A1 553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.