Sugi Predict

Sugi Predict / Compounds / SCHEMBL1614175

SCHEMBL1614175

SCHEMBL1614175

COc1ccc(OC)c2c(=O)c3ccccc3sc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.64
▸ NPC1 O15118 3/20 0.64
▸ RAB9A P51151 3/20 0.64
▸ HPGD P15428 3/20 0.64
▸ CYP1A2 P05177 1/20 0.64
▸ CYP3A4 P08684 1/20 0.64
▸ CYP2C9 P11712 1/20 0.64
▸ CYP2C19 P33261 1/20 0.64
▸ ALDH1A1 P00352 5/20 0.49
▸ TDP1 Q9NUW8 3/20 0.49
▸ KDM4E B2RXH2 3/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.49
▸ MAOA P21397 2/20 0.46
▸ ABCG2 Q9UNQ0 1/20 0.45
▸ HCRTR1 O43613 2/20 0.43
▸ POLB P06746 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MEN1 O00255 3/20 0.43
▸ KMT2A Q03164 3/20 0.43
▸ HTT P42858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21206935 0.91 MAPT (0.61) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL25556876 0.88 MAPT (0.58) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL13798431 0.88 MAPT (0.58) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL29936552 0.88 MAPT (0.58) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL25556885 0.88 MAPT (0.58) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL6483685 0.84 HPGD (0.51) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL30925001 0.82 NPC1 (0.70) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL2789108 0.82 NPC1 (0.70) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL5030886 0.82 MAPT (0.54) MAPTNPC1RAB9AHPGDCYP1A2
SCHEMBL30998134 0.82 MAPT (0.54) MAPTNPC1RAB9AHPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11001602-B2 Diarylsulfide backbone containing photolabile protecting groups ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2021-05-11 — — US disclosed
US-20190112328-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS NIMBLEGEN SYSTEMS GMBH (DE) 2019-04-18 — — US disclosed
US-10150791-B2 Diarylsulfide backbone containing photolabile protecting groups ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2018-12-11 — — US disclosed
CN-103649102-B The blocking group to photo-labile comprising diaryl sulfide skeleton 霍夫曼-拉罗奇有限公司 2017-06-09 — — CN disclosed
US-20170145047-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS NIMBLEGEN SYSTEMS GMBH (DE) 2017-05-25 — — US disclosed
US-20160060286-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS NIMBLEGEN SYSTEMS GMBH (DE) 2016-03-03 — — US disclosed
EP-2694525-B1 DIARYLSULPHID BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS ROCHE DIAGNOSTICS GMBH (DE) 2015-07-08 — — EP disclosed
US-20140051605-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS NIMBLEGEN SYSTEMS GMBH (DE) 2014-02-20 — — US disclosed
US-20120258891-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS NIMBLEGEN SYSTEMS GMBH (DE) 2012-10-11 — — US disclosed
US-8097688-B2 Ink composition and inkjet recording method FUJIFILM CORPORATION (JP) 2012-01-17 — — US disclosed
US-20060121389-A1 Melts ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2006-06-08 — — US disclosed
EP-1630600-A2 Hot melt composition and method involving forming a masking pattern Rohm and Haas Electronic Materials, L.L.C. (US) 2006-03-01 — — EP disclosed
US-20050255403-A1 Method for cleavage of labile functional groups from chemical compounds UNIVERSITAT KONSTANZ (DE) 2005-11-17 — — US disclosed
US-20050170281-A1 Method of cleaving labile functional groups from chemical compounds NIMBLEGEN SYSTEMS, INC. 2005-08-04 — — US disclosed
EP-1519941-A2 A METHOD OF CLEAVING LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS Chemogenix GmbH (DE) 2005-04-06 — — EP disclosed
EP-1480927-A2 A METHOD FOR CLEAVAGE OF LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS Universität Konstanz (DE) 2004-12-01 — — EP disclosed
WO-2004001033-A2 A METHOD OF CLEAVING LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS CHEMOGENIX GMBH (DE) 2003-12-31 — — WO disclosed
WO-2003074542-A2 A METHOD FOR CLEAVAGE OF LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS Universität Konstanz (DE) 2003-09-12 — — WO disclosed
US-5414092-A Photoinitiators INTERNATIONAL BIO-SYNTHETICS LIMITED (GB) 1995-05-09 — — US disclosed
EP-0520574-A1 Thioxanthone derivatives GREAT LAKES FINE CHEMICALS LIMITED (GB) 1992-12-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001602-B2 Diarylsulfide backbone containing photolabile protecting groups CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-20160060286-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-20120258891-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-20190112328-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-20170145047-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-20140051605-A1 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885
US-10150791-B2 Diarylsulfide backbone containing photolabile protecting groups CRY2, PRXL2A, MGMT MAPT 3600/4885NPC1 4703/4885RAB9A 660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.