Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17518804 | 0.87 | HRH3 (0.46) | HPGDSSIGMAR1HRH3BRD4CREBBP | |
| SCHEMBL17516261 | 0.84 | SIGMAR1 (0.40) | HPGDSSIGMAR1HRH3POLBPDK2 | |
| SCHEMBL5777653 | 0.81 | ESR2 (0.46) | HPGDSSIGMAR1PDK2 | |
| SCHEMBL17518863 | 0.78 | SIGMAR1 (0.40) | SIGMAR1HRH3 | |
| SCHEMBL6109607 | 0.78 | HPGDS (0.54) | HPGDSNPC1RAB9AGRM5BRD4 | |
| SCHEMBL6109258 | 0.74 | HPGDS (0.50) | HPGDSNPC1RAB9AGRM5POLB | |
| SCHEMBL17516291 | 0.74 | SIGMAR1 (0.37) | SIGMAR1 | |
| SCHEMBL15932471 | 0.71 | HPGDS (0.45) | HPGDSNPC1RAB9A | |
| SCHEMBL13955199 | 0.70 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL4528342 | 0.70 | CTSS (0.42) | POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160592-A2 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | WO | disclosed |