Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516507 | 0.91 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL2239446 | 0.91 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL25154183 | 0.91 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL16053523 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4NR1H2 | |
| SCHEMBL17112600 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4NR1H2 | |
| SCHEMBL584860 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4NR1H2 | |
| SCHEMBL14222418 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4NR1H2 | |
| SCHEMBL649983 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4NR1H2 | |
| SCHEMBL26116742 | 0.85 | GPR119 (0.48) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14497251 | 0.85 | HPGD (0.45) | MEN1ALDH1A1MAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856264-B2 | Isoquinolinesulfonyl derivative as RHO kinase inhibitor | MEDSHINE DISCOVERY INC. (CN) | 2018-01-02 | — | — | US | disclosed |
| EP-3138843-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | Medshine Discovery Inc. (CN) | 2017-03-08 | — | — | EP | disclosed |
| EP-3138843-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | Medshine Discovery Inc. (CN) | 2017-03-08 | — | — | EP | disclosed |
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2017-02-09 | — | — | US | disclosed |
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2017-02-09 | — | — | US | disclosed |
| WO-2015165341-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | 南京明德新药研发股份有限公司 | 2015-11-05 | — | — | WO | disclosed |
| WO-2014160592-A2 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037050-A1 | ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR | ROCK1, ROCK2, CIT | MEN1 3330/4885ALDH1A1 3120/4885MAPT 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.