Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16144706 | 0.94 | PDE4B (0.70) | HTR7PDE4BDRD4MAPK1KDM4E | |
| SCHEMBL16282481 | 0.88 | HTR7 (0.74) | HTR7DRD4MAPK1KDM4EALDH1A1 | |
| SCHEMBL15938696 | 0.85 | HTR7 (1.00) | HTR7DRD4KDM4EMAPTDRD2 | |
| SCHEMBL15937972 | 0.84 | HTR7 (1.00) | HTR7DRD4MAPK1DRD2DRD3 | |
| SCHEMBL15938805 | 0.83 | HTR7 (0.83) | HTR7DRD4MAPK1KDM4EMAPT | |
| SCHEMBL6031061 | 0.81 | MAPK1 (0.80) | HTR7DRD4MAPK1KDM4EMAPT | |
| SCHEMBL16281852 | 0.81 | HTR7 (0.74) | HTR7DRD4MAPK1KDM4EALDH1A1 | |
| SCHEMBL16282478 | 0.81 | HTR7 (0.63) | HTR7PDE4BDRD4KDM4EMAPT | |
| SCHEMBL7991732 | 0.79 | DRD4 (1.00) | HTR7DRD4MAPK1KDM4EALDH1A1 | |
| SCHEMBL15937822 | 0.79 | HTR7 (0.85) | HTR7DRD4MAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784068-B1 | PHOSPHODIESTERASE 4 INHIBITOR CAPABLE OF AVOIDING VOMITING | XU JIANGPING (CN) | 2015-10-21 | — | — | EP | disclosed |
| EP-2784068-A1 | PHOSPHODIESTERASE 4 INHIBITOR CAPABLE OF AVOIDING VOMITING | Xu, Jiangping (CN) | 2014-10-01 | — | — | EP | disclosed |