Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.70 |
| ▸ | HTR7 | P34969 | 5/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16144703 | 0.94 | HTR7 (0.74) | PDE4BHTR7DRD4KDM4EALDH1A1 | |
| SCHEMBL16144711 | 0.82 | PDE4B (0.51) | PDE4BHTR7ALDH1A1MAPTKMT2A | |
| SCHEMBL16282481 | 0.82 | HTR7 (0.74) | HTR7DRD4KDM4EALDH1A1ALOX15 | |
| SCHEMBL16282478 | 0.81 | HTR7 (0.63) | PDE4BHTR7DRD4KDM4EALDH1A1 | |
| SCHEMBL15938805 | 0.81 | HTR7 (0.83) | HTR7DRD4KDM4EMAPTMAPK1 | |
| SCHEMBL6132073 | 0.80 | ALDH1A1 (0.66) | HTR7DRD4KDM4EALDH1A1MAPT | |
| SCHEMBL15938696 | 0.78 | HTR7 (1.00) | HTR7DRD4KDM4EMAPTDRD2 | |
| SCHEMBL15937972 | 0.78 | HTR7 (1.00) | HTR7DRD4MAPK1DRD2DRD3 | |
| SCHEMBL6904904 | 0.76 | USP2 (0.66) | HTR7KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL4326721 | 0.75 | PDE4B (0.61) | PDE4BHTR7ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784068-B1 | PHOSPHODIESTERASE 4 INHIBITOR CAPABLE OF AVOIDING VOMITING | XU JIANGPING (CN) | 2015-10-21 | — | — | EP | disclosed |
| EP-2784068-A1 | PHOSPHODIESTERASE 4 INHIBITOR CAPABLE OF AVOIDING VOMITING | Xu, Jiangping (CN) | 2014-10-01 | — | — | EP | disclosed |