Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.62 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.62 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877577 | 0.92 | SIRT5 (0.68) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL1160192 | 0.92 | SIRT5 (0.68) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL13449701 | 0.90 | SIRT2 (0.69) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL8079485 | 0.82 | SIRT5 (0.80) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL1160328 | 0.81 | SIRT5 (0.67) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL13449700 | 0.80 | SIRT2 (0.67) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL5465199 | 0.80 | HDAC6 (0.67) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| SCHEMBL5459176 | 0.79 | HDAC6 (0.64) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| SCHEMBL5459171 | 0.79 | HDAC6 (0.64) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| SCHEMBL17742350 | 0.79 | SIRT2 (0.69) | SIRT2SIRT1SIRT5SIRT3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459553-B1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | BASILEA PHARMACEUTICA AG (CH) | 2014-10-01 | — | — | EP | disclosed |