Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.53 |
| ▸ | RXRB | P28702 | 15/20 | 0.53 |
| ▸ | RXRG | P48443 | 14/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.52 |
| ▸ | RARB | P10826 | 6/20 | 0.51 |
| ▸ | RARG | P13631 | 6/20 | 0.51 |
| ▸ | RARA | P10276 | 4/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459952 | 0.80 | RXRA (0.66) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL5865567 | 0.76 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL24750771 | 0.76 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL5084734 | 0.74 | CYP26B1 (0.75) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL13027020 | 0.72 | RXRA (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5179870 | 0.71 | RXRA (0.72) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8674739 | 0.71 | RXRA (0.65) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8733241 | 0.71 | RARB (0.83) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL23449193 | 0.71 | RXRA (0.48) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL9446455 | 0.71 | RXRA (0.52) | RXRARXRBRXRGCYP26B1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923579-B2 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | EXONHIT THERAPEUTICS S.A. (FR) | 2011-04-12 | — | — | US | disclosed |
| EP-1692097-B1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2009-09-02 | — | — | EP | disclosed |