Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.83 |
| ▸ | RARG | P13631 | 12/20 | 0.83 |
| ▸ | RXRA | P19793 | 12/20 | 0.83 |
| ▸ | RXRB | P28702 | 8/20 | 0.83 |
| ▸ | RXRG | P48443 | 6/20 | 0.83 |
| ▸ | RARA | P10276 | 10/20 | 0.76 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.76 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355871 | 0.91 | RXRA (1.00) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL24259973 | 0.91 | RXRA (0.77) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL2194599 | 0.91 | RARB (0.82) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL16523407 | 0.90 | RARB (0.74) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7761329 | 0.87 | RARB (0.80) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7422927 | 0.87 | RXRA (0.70) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL10356129 | 0.87 | CYP26A1 (0.71) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL2391376 | 0.87 | RARB (1.00) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL2195224 | 0.86 | RXRA (0.66) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL846110 | 0.86 | RARB (0.81) | RARBRARGRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699178-B1 | TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN INC (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5696162-A | ANTIINFLAMMATORY AGENTS, SKIN DISORDERS, AUTOIMMUNE DISORDERS | ALLERGAN (US) | 1997-12-09 | — | — | US | disclosed |
| US-5677320-A | SKIN DISORDERS, ANTIGROWTH AGENT, IMMUNOLOGY DISORDERS | ALLERGAN (US) | 1997-10-14 | — | — | US | disclosed |
| US-5602135-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ARTHEROSCLEROSIS,IMMUNOLOGY, WOUND HEALING AGENT, VISION DEFECTS, SUNSCREEN AGENTS | ALLERGAN | 1997-02-11 | — | — | US | disclosed |
| US-5475022-A | Treating acne | ALLERGAN, INC. (US) | 1995-12-12 | — | — | US | disclosed |
| WO-1995011242-A1 | PHENYL OR HETEROARYL AND TETRAHYDRONAPHTHYL SUBSTITUTED DIENE COMPOUNDS HAVING RETINOID LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1995-04-27 | — | — | WO | disclosed |
| WO-1994026687-A1 | TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5344959-A | Skin disorders and anticancer agents | ALLERGAN, INC. (US) | 1994-09-06 | — | — | US | disclosed |