Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.75 |
| ▸ | RXRA | P19793 | 14/20 | 0.66 |
| ▸ | RXRB | P28702 | 10/20 | 0.66 |
| ▸ | RARB | P10826 | 11/20 | 0.65 |
| ▸ | RARG | P13631 | 10/20 | 0.65 |
| ▸ | RXRG | P48443 | 8/20 | 0.65 |
| ▸ | RARA | P10276 | 8/20 | 0.62 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459952 | 0.92 | RXRA (0.66) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL22838105 | 0.86 | CYP26B1 (1.00) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL8457579 | 0.84 | RXRA (0.59) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL14425232 | 0.84 | CYP26B1 (0.65) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL5080300 | 0.83 | RXRA (0.61) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL29827631 | 0.82 | RARB (0.81) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL846110 | 0.82 | RARB (0.81) | CYP26B1RXRARXRBRARBRARG | |
| SCHEMBL13027020 | 0.82 | RXRA (0.67) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL8839229 | 0.81 | RXRA (0.64) | CYP26B1RXRARXRBRARBRARG | |
| Hydrochloric Acid SCHEMBL9120757 | 0.80 | RARB (0.78) | CYP26B1RXRARXRBRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465343-B1 | Pharmaceutical or cosmetical composition comprising a retinoid and a sterol in association | CIRD GALDERMA (FR) | 1994-06-15 | — | — | EP | claimed |
| US-20080255244-A1 | Administering a Calmodulin-dependent protein kinase (M kinase II) gamma inhibitor; acute myelogenous leukemia, chronic myelogenous leukemia, gastrointestinal stromal tumor, small cell lung cancer, non-small cell lung cancer, ovarian cancer | FRED HUTCHINSON CANCER RESEARCH CENTER | 2008-10-16 | — | — | US | disclosed |
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5587367-A | SYNERGISTIC EFFECT IN TREATING SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1996-12-24 | — | — | US | disclosed |
| US-5556844-A | SYNERGISTIC, SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1996-09-17 | — | — | US | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |