Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081798 | 0.87 | ESR1 (0.59) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL2220712 | 0.87 | TRPA1 (0.56) | ALDH1A1TRPA1TSHRMAOBESR1 | |
| SCHEMBL9154487 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL4810276 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL9579598 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL9253594 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL8496560 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL177117 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL8702332 | 0.85 | ESR1 (0.63) | ALDH1A1TSHRESR1ADRA2AADORA3 | |
| SCHEMBL14072861 | 0.85 | CA2 (0.53) | ALDH1A1TRPA1TSHRESR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240299589-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-09-12 | — | — | US | disclosed |
| US-11813338-B2 | Diagnosing and treating cancer | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-11-14 | — | — | US | disclosed |
| US-11813338-B2 | Diagnosing and treating cancer | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-11-14 | — | — | US | disclosed |
| US-11813338-B2 | Diagnosing and treating cancer | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-11-14 | — | — | US | disclosed |
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2014165216-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014165216-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | CHKA, CHKB, CILK1 | ALDH1A1 1793/4885TRPA1 3959/4885TSHR 4640/4885 |
| US-20240299589-A1 | DIAGNOSING AND TREATING CANCER | CHKA, CHKB, CILK1 | ALDH1A1 1793/4885TRPA1 3959/4885TSHR 4640/4885 |
| US-11813338-B2 | Diagnosing and treating cancer | CHKA, CHKB, CILK1 | ALDH1A1 1793/4885TRPA1 3959/4885TSHR 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.