Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | BAG3 | O95817 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614993 | 0.88 | SLC2A1 (0.64) | PRKAG1PRKAA1PRKAB1SLC2A1AURKA | |
| SCHEMBL1614991 | 0.88 | SLC2A1 (0.64) | PRKAG1PRKAA1PRKAB1SLC2A1AURKA | |
| SCHEMBL1613699 | 0.88 | SLC2A1 (0.64) | PRKAG1PRKAA1PRKAB1SLC2A1AURKA | |
| SCHEMBL12712444 | 0.87 | AURKA (0.51) | PRKAG1PRKAA1PRKAB1SLC2A1COMT | |
| SCHEMBL2174274 | 0.83 | AURKA (0.53) | PRKAG1PRKAA1PRKAB1SLC2A1COMT | |
| SCHEMBL2174270 | 0.83 | AURKA (0.53) | PRKAG1PRKAA1PRKAB1SLC2A1COMT | |
| SCHEMBL2172739 | 0.82 | AURKA (0.48) | PRKAG1PRKAA1PRKAB1COMTAURKA | |
| SCHEMBL2172737 | 0.82 | AURKA (0.48) | PRKAG1PRKAA1PRKAB1COMTAURKA | |
| SCHEMBL1614016 | 0.81 | SLC2A1 (0.48) | SLC2A1COMTAKR1B1BAG3PPARG | |
| SCHEMBL1614013 | 0.81 | SLC2A1 (0.48) | SLC2A1COMTAKR1B1BAG3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | claimed |
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | PCK2, AK2, SIRT6 | PRKAG1 25/4885PRKAA1 65/4885PRKAB1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.