Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982425 | 0.75 | KMT2A (0.39) | ALDH1A1LMNAGAASMN1; SMN2NPSR1 | |
| SCHEMBL6982420 | 0.75 | KMT2A (0.39) | ALDH1A1LMNAGAASMN1; SMN2NPSR1 | |
| SCHEMBL17592502 | 0.75 | HTR7 (0.54) | HTR7TMEM97 | |
| SCHEMBL16149050 | 0.75 | HTR7 (0.54) | HTR7TMEM97 | |
| SCHEMBL17592850 | 0.75 | HTR7 (0.54) | HTR7TMEM97 | |
| SCHEMBL17592845 | 0.73 | HTR7 (0.54) | HTR7TMEM97 | |
| SCHEMBL3454507 | 0.70 | CYP2D6 (0.44) | ALDH1A1LMNAGAASMN1; SMN2POLB | |
| SCHEMBL10832402 | 0.68 | ALDH1A1 (0.51) | ALDH1A1LMNAGAASMN1; SMN2NPSR1 | |
| SCHEMBL17435858 | 0.68 | HTR7 (0.59) | HTR7 | |
| SCHEMBL14780181 | 0.68 | TSHR (0.45) | ALDH1A1GAASMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970223-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | Temple University Of The Commonwealth System Of Higher Education (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014164756-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-10-09 | — | — | WO | disclosed |