Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16031154 | 0.91 | CYP27B1 (0.49) | KMT2ASMN1; SMN2SPHK2SPHK1 | |
| SCHEMBL16032640 | 0.88 | GPR132 (0.56) | — | |
| SCHEMBL3963466 | 0.88 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2 | |
| SCHEMBL16030861 | 0.87 | GPR132 (0.43) | KMT2ASMN1; SMN2ALOX5 | |
| SCHEMBL15232863 | 0.87 | KMT2A (0.57) | KMT2ASMN1; SMN2SPHK2SPHK1NR4A2 | |
| SCHEMBL16031455 | 0.85 | KMT2A (0.48) | KMT2ASMN1; SMN2SPHK2SPHK1NR4A2 | |
| SCHEMBL16031452 | 0.85 | KMT2A (0.48) | KMT2ASMN1; SMN2SPHK2SPHK1NR4A2 | |
| SCHEMBL16031784 | 0.85 | GPR132 (0.48) | KMT2ASMN1; SMN2ALOX5MEN1 | |
| SCHEMBL29818763 | 0.83 | KMT2A (0.58) | KMT2ASMN1; SMN2NR4A2MEN1MAOB | |
| SCHEMBL2207119 | 0.83 | KMT2A (0.58) | KMT2ASMN1; SMN2NR4A2MEN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970099-A1 | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014164905-A1 | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2014-10-09 | — | — | WO | disclosed |