Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SI | P14410 | 2/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492979 | 0.79 | MEN1 (0.59) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16151416 | 0.79 | ALDH1A1 (0.76) | LMNAALDH1A1MAPTHTTPOLB | |
| SCHEMBL16150878 | 0.79 | LCK (0.61) | LMNAALDH1A1MAPTHTTPOLB | |
| SCHEMBL2617065 | 0.75 | MAPT (0.59) | LMNAALDH1A1MAPTHTTPOLB | |
| SCHEMBL11337809 | 0.75 | HDAC6 (0.57) | LMNAALDH1A1MAPTHTTPOLB | |
| SCHEMBL16150617 | 0.73 | EGFR (0.64) | ALDH1A1MAPTHTTPOLBTP53 | |
| SCHEMBL14740460 | 0.72 | ALDH1A1 (0.62) | LMNAALDH1A1MAPTHTTPOLB | |
| SCHEMBL22117122 | 0.70 | NPC1 (0.53) | LMNAMAPTHTTPOLBTP53 | |
| SCHEMBL8050623 | 0.70 | PDK1 (0.60) | LMNAALDH1A1MAPTHTTMEN1 | |
| SCHEMBL11117696 | 0.70 | PKM (0.47) | LMNAALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014161516-A1 | OXA- AND THIA-DIAZOLES USEFUL IN THE TREATMENT OF TUBERCULOSIS | UNIVERZITA KARLOVA V PRAZE FARMACEUTICKA FAKULTA V HRADCI KRALOVE (CZ) | 2014-10-09 | — | — | WO | disclosed |