Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437789 | 0.89 | HPGD (0.40) | HDAC6HDAC3HDAC1HDAC4HDAC2 | |
| SCHEMBL4403236 | 0.85 | GSTP1 (0.45) | HDAC6KCNH2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4403233 | 0.85 | GSTP1 (0.41) | HDAC6KCNH2KMT2AMEN1ALDH1A1 | |
| SCHEMBL12671652 | 0.85 | HDAC6 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC2 | |
| SCHEMBL15976894 | 0.84 | HDAC3 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC2 | |
| SCHEMBL16503905 | 0.83 | LMNA (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC2 | |
| SCHEMBL13193883 | 0.83 | GSTP1 (0.43) | HDAC6KCNH2KMT2AMEN1ALDH1A1 | |
| SCHEMBL13881238 | 0.82 | GSTP1 (0.46) | HDAC6HPGDKCNH2KMT2AMEN1 | |
| SCHEMBL12018901 | 0.82 | HDAC6 (0.34) | HDAC6HDAC3HDAC1HDAC4HDAC2 | |
| SCHEMBL14330482 | 0.82 | HDAC3 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1782071-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORP (US) | 2014-10-08 | — | — | EP | disclosed |