Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12018903 | 0.93 | GAA (0.34) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL16503905 | 0.87 | LMNA (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL12925030 | 0.86 | MAPT (0.40) | HDAC3SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL14330482 | 0.86 | HDAC3 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL4403236 | 0.84 | GSTP1 (0.45) | HDAC6MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL4437789 | 0.84 | HPGD (0.40) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL15976894 | 0.84 | HDAC3 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL12671652 | 0.83 | HDAC6 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL4403233 | 0.83 | GSTP1 (0.41) | HDAC6MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL16153101 | 0.82 | HDAC6 (0.33) | HDAC6HDAC3HDAC1HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220013-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2012-08-30 | — | — | US | disclosed |
| US-RE42931-E1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2011-11-15 | — | — | US | disclosed |
| US-7867726-B2 | Compositions comprising a dehalogenase substrate and a fluorescent label and methods of use | PROMEGA CORPORATION (US) | 2011-01-11 | — | — | US | disclosed |
| US-7429472-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION | 2008-09-30 | — | — | US | disclosed |
| US-20080026407-A1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080026407-A1 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | HDAC6 1560/4885HDAC3 2536/4885HDAC1 2263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.