Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKBIA | P25963 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242607 | 0.81 | GBA1 (0.40) | LMNASCN1ASCN5ASCN8ASMN1; SMN2 | |
| SCHEMBL1616346 | 0.81 | MEN1 (0.46) | KMT2AMEN1LMNASCN1ASCN5A | |
| SCHEMBL2919481 | 0.80 | SCN1A (0.41) | LMNASCN1ASCN5ASCN8ASMN1; SMN2 | |
| SCHEMBL1616265 | 0.80 | SCN1A (0.41) | LMNASCN1ASCN5ASCN8ASMN1; SMN2 | |
| SCHEMBL2926162 | 0.80 | SCN1A (0.41) | KMT2AMEN1LMNASCN1ASCN5A | |
| SCHEMBL1615546 | 0.80 | SCN1A (0.41) | KMT2AMEN1LMNASCN1ASCN5A | |
| SCHEMBL3844986 | 0.78 | PDPK1 (0.47) | FADS1CA2GBA1 | |
| SCHEMBL1616405 | 0.77 | GLO1 (0.45) | KMT2ALMNASMN1; SMN2ALOX15L3MBTL1 | |
| SCHEMBL1616159 | 0.77 | PRKCQ (0.39) | KMT2AMEN1LMNASCN1ASCN5A | |
| SCHEMBL1616691 | 0.76 | PFKFB3 (0.39) | LMNASCN1ASCN5ASCN8ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923561-B2 | Quinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-04-12 | — | — | US | claimed |
| US-7923561-B2 | Quinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-04-12 | — | — | US | disclosed |