Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16154997 | 0.88 | KDM4E (0.46) | KDM4ECYP1A2CYP2A6SCN9APSMD14 | |
| SCHEMBL14893850 | 0.84 | KDM4E (0.50) | KDM4ESCN9APSMD14ALDH1A1HPGD | |
| SCHEMBL14893790 | 0.84 | ALDH1A1 (0.46) | KDM4ESCN9APSMD14ALDH1A1HPGD | |
| SCHEMBL31522776 | 0.83 | NR4A1 (0.50) | KDM4ECYP1A2CYP2A6ALDH1A1HPGD | |
| SCHEMBL31522781 | 0.81 | KDM4E (0.56) | KDM4ECYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL19733167 | 0.80 | ALDH1A1 (0.56) | KDM4ESCN9AALDH1A1HPGDNPSR1 | |
| SCHEMBL31522787 | 0.80 | L3MBTL1 (0.52) | ALDH1A1SLC6A2SLC6A3TSHRMEN1 | |
| SCHEMBL29403597 | 0.79 | ALDH1A1 (0.54) | KDM4ESCN9AALDH1A1HPGDNPSR1 | |
| SCHEMBL6761980 | 0.79 | ALDH1A1 (0.54) | KDM4ESCN9AALDH1A1HPGDNPSR1 | |
| SCHEMBL1595439 | 0.78 | LMNA (0.46) | KDM4ESCN9APSMD14ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273040-B2 | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels | MERCK SHARP & DOHME CORP. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140303143-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC | 2014-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303143-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | SCN7A, SCN1A, CACNA1E | KDM4E 1753/4885CYP1A2 1243/4885CYP2A6 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.