Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R8 | Q9NYW2 | 7/20 | 0.67 |
| ▸ | CACNA1G | O43497 | 10/20 | 0.53 |
| ▸ | CACNA1I | Q9P0X4 | 10/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614809 | 0.94 | TAS2R8 (0.69) | TAS2R8CACNA1GCACNA1ICACNA1HRAB9A | |
| SCHEMBL1615571 | 0.89 | CACNA1G (0.67) | TAS2R8CACNA1GCACNA1ICACNA1HCACNA1C | |
| SCHEMBL1615590 | 0.83 | TAS2R8 (0.47) | TAS2R8CACNA1GCACNA1ICACNA1H | |
| SCHEMBL1615273 | 0.83 | TAS2R8 (0.65) | TAS2R8RAB9A | |
| SCHEMBL1614813 | 0.82 | TAS2R8 (0.68) | TAS2R8CACNA1GCACNA1ICACNA1H | |
| SCHEMBL1615825 | 0.81 | TAS2R8 (0.48) | TAS2R8 | |
| SCHEMBL15114689 | 0.81 | TAS2R8 (0.52) | TAS2R8CACNA1GCACNA1ICACNA1H | |
| SCHEMBL1615679 | 0.80 | TAS2R8 (1.00) | TAS2R8 | |
| SCHEMBL1614797 | 0.80 | TAS2R8 (0.69) | TAS2R8CACNA1GCACNA1ICACNA1H | |
| SCHEMBL1615292 | 0.79 | TAS2R8 (0.67) | TAS2R8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9247759-B2 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9247759-B2 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | SENOMYX, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | SENOMYX, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-8445692-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445692-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120088796-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF | SENOMYX, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-20120088796-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF | SENOMYX, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-8148544-B2 | Compounds that inhibit (block) bitter taste in composition and methods of making same | SENOMYX, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148544-B2 | Compounds that inhibit (block) bitter taste in composition and methods of making same | SENOMYX, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| WO-2011106114-A1 | IDENTIFICATION OF HUMAN T2R RECEPTORS AND THE USE THEREOF TO IDENTIFY INHIBITORS (BLOCKERS) OF BITTER TASTE | SENOMYX, INC. (US) | 2011-09-01 | — | — | WO | disclosed |
| US-20110207937-A1 | Compounds that inhibit (block) bitter taste in composition and methods of making same | SENOMYX, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110207937-A1 | Compounds that inhibit (block) bitter taste in composition and methods of making same | SENOMYX, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-7939671-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7939671-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20100254916-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100254916-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20090274632-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX, INC. (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090274632-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX, INC. (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2009025793-A2 | HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF | SENOMYX, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207937-A1 | Compounds that inhibit (block) bitter taste in composition and methods of making same | TAS2R50, TAS2R1, TAS2R5 | TAS2R8 19/4885CACNA1G 445/4885CACNA1I 441/4885 |
| US-20090274632-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof | TAS2R50, TAS2R1, TAS2R30 | TAS2R8 18/4885CACNA1G 715/4885CACNA1I 682/4885 |
| US-20120088796-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF | TAS2R50, TAS2R5, TAS2R1 | TAS2R8 20/4885CACNA1G 472/4885CACNA1I 444/4885 |
| US-20100254916-A1 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | TAS2R50, TAS2R1, TAS2R30 | TAS2R8 16/4885CACNA1G 702/4885CACNA1I 681/4885 |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | TAS2R50, TAS2R1, TAS2R5 | TAS2R8 19/4885CACNA1G 445/4885CACNA1I 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.