Helenalin

Helenalin

SCHEMBL161594

C=C1C(=O)OC2CC(C)C3C=CC(=O)C3(C)C(O)C12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 1.00
RAB9A P51151 6/20 1.00
NPC1 O15118 5/20 1.00
HTT P42858 5/20 1.00
XBP1 P17861 4/20 1.00
MDM2 Q00987 4/20 1.00
POLB P06746 4/20 1.00
MAPK1 P28482 3/20 1.00
AGTR1 P30556 3/20 1.00
GPR55 Q9Y2T6 3/20 1.00
TERT O14746 1/20 1.00
ALDH1A1 P00352 1/20 1.00
GLA P06280 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
PAX8 Q06710 1/20 0.72
RECQL P46063 2/20 0.69
THRB P10828 1/20 0.69
OPRK1 P41145 1/20 0.69
BLM P54132 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Helenalin SCHEMBL10099625 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Helenalin SCHEMBL161593 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Helenalin SCHEMBL31237389 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Helenalin SCHEMBL10132557 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Helenalin SCHEMBL11030579 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Mexicanin I SCHEMBL17238871 1.00 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
SCHEMBL15497257 0.90 MAPT (0.81) MAPTRAB9ANPC1HTTXBP1
SCHEMBL26240747 0.90 MAPT (0.81) MAPTRAB9ANPC1HTTXBP1
Angustibalin SCHEMBL509228 0.84 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1
Bigelovin SCHEMBL29349709 0.84 MAPT (1.00) MAPTRAB9ANPC1HTTXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1408 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 EP claimed
US-12569494-B2 Compositions and methods to promote thymic regeneration FRED HUTCHINSON CANCER CENTER (US) 2026-03-10 US claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
EP-4631513-A1 OPHTHALMIC FORMULATION FOR TOPICAL USE CONTAINING HELENALIN, 11A,13-DIHYDRO HELENALIN AND FLAVONOIDS FROM ARNICA MONTANA EXTRACT AND SODIUM HYALURONATE, AND USE THEREOF BY HUMANS TO TREAT DRY EYE SYNDROME Centro de Retina Médica Y Quirúrgica, S.C. (MX) 2025-10-15 EP claimed
US-12285488-B2 Oral dosage form containing theobromine-free cocoa LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2025-04-29 US claimed
WO-2025071390-A1 LIPID-BASED FORMULATION CONTAINING HELENALIN FOR TOPICAL OPHTHALMIC USE WITH APPLICATION IN THE MODULATION OF THE INFLAMMATORY PROCESS OF THE OCULAR SURFACE AND IN THE TREATMENT OF DRY EYE CENTRO DE RETINA MÉDICA Y QUIRÚRGICA, S.C. (MX) 2025-04-03 WO claimed
US-20240269196-A1 RESPIRATORY TREATMENTS USING SALMONID OIL COMPOSITIONS HOFSETH BIOCARE ASA (NO) 2024-08-15 US claimed
WO-2024123165-A1 OPHTHALMIC FORMULATION FOR TOPICAL USE CONTAINING HELENALIN, 11Α,13-DIHYDRO HELENALIN AND FLAVONOIDS FROM ARNICA MONTANA EXTRACT AND SODIUM HYALURONATE, AND USE THEREOF BY HUMANS TO TREAT DRY EYE SYNDROME CENTRO DE RETINA MÉDICA Y QUIRÚRGICA, S.C. (MX) 2024-06-13 WO claimed
EP-4157458-B1 TRIARYLPYRIDINE COMPOUNDS AND USE THEREOF FOR TREATING CANCER INST NAT SANTE RECH MED (FR) 2024-04-17 EP claimed
EP-1435877-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS Hemoteq GmbH (DE) 2004-07-14 EP claimed
US-20040115289-A1 Cosmetic or medicinal composition containing sesquiterpene lactone or the like for treating hair -growth related disorders, and preparation method IMD (FR) 2004-06-17 US claimed
WO-2003094990-A1 COMPOUNDS AND METHOD FOR COATING SURFACES IN A HAEMOCOMPATIBLE MANNER HEMOTEQ GMBH (DE) 2003-11-20 WO claimed
WO-2003034944-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS HEMOTEQ GMBH (DE) 2003-05-01 WO claimed
US-20020076452-A1 Combinations of sesquiterpene lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2 ASHNI NATURACEUTICALS, INC. 2002-06-20 US claimed
US-20020077350-A1 Compositions exhibiting synergistic inhibition of the expression and/or activity of clyclooxygenase-2 ASHNI NATURACEUTICALS, INC. 2002-06-20 US claimed
US-20020077299-A1 Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2 META PROTEOMICS, LLC 2002-06-20 US claimed
WO-2002009698-A1 COMPOSITIONS EXHIBITING SYNERGISTIC INHIBITION OF THE EXPRESSION AND/OR ACTIVITY OF CYCLOOXYGENASE-2 ASHNI NATURACEUTICALS, INC. (US) 2002-02-07 WO claimed
WO-1998038971-A1 THERAPEUTIC COMPOSITION AND METHOD FOR TREATING SKIN USING CENTIPEDA CUNNINGHAMI EXTRACT BIO-BOTANICA, INC. (US) 1998-09-11 WO claimed
US-5804206-A PROVIDING PLANT MATERIAL OF CENTIPEDA GENUS IN POWDER FORM, SEQUENTIALLY MACERATING AND EXTRACTING WITH PLURALITY OF AQUEOUS/ETHANOLIC SOLVENTS OF DIFFERENT CONCENTRATION, COMBINING SOLUTIONS BIO-BOTANICA, INC. (US) 1998-09-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12569494-B2 Compositions and methods to promote thymic regeneration CDC42, BMP4, TPMT MAPT 1997/4885RAB9A 688/4885NPC1 3051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.