Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.44 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15258671 | 0.93 | HDAC3 (0.47) | HDAC4HSD11B1WDR91CCR2HDAC1 | |
| SCHEMBL2712662 | 0.83 | SSTR4 (0.53) | HDAC4HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL16249346 | 0.82 | WDR91 (0.53) | WDR91HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL2173859 | 0.82 | ALDH1A1 (0.41) | HDAC1HDAC3HDAC2HDAC6SSTR4 | |
| SCHEMBL361827 | 0.82 | MAPK1 (0.39) | HDAC4HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL3560390 | 0.79 | SSTR4 (0.56) | HDAC4HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL17872724 | 0.79 | WDR91 (0.41) | HDAC4HSD11B1WDR91CCR2HDAC1 | |
| SCHEMBL27224162 | 0.79 | ALDH1A1 (0.40) | HDAC1HDAC3HDAC2HDAC6SSTR4 | |
| SCHEMBL17872726 | 0.79 | WDR91 (0.41) | HDAC4HSD11B1WDR91CCR2HDAC1 | |
| SCHEMBL2699856 | 0.79 | MAPT (0.40) | HDAC1HDAC3HDAC2HDAC6SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104669-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2014-10-15 | — | — | EP | disclosed |